Intestinal fibrosis: a new therapeutic target?
Laura Stronati1, Salvatore Cucchiara2
1Dipartimento di Medicina Molecolare, Sapienza Università di Roma 2Dipartimento Materno Infantile, Sapienza Università di Roma
Fibrosis is a serious complication of inflammatory bowel disease (IBD). Mesenchymal cells, fibroblasts, myofibroblasts and smooth muscle cells mainly activate fibrogenesis. Currently, therapies include medical treatment targeting the inflammatory component of stenosis, endoscopic treatment, and surgery. Innovative therapies include TGF-β inhibitors, immunotherapy with autologous T regulatory cells, pluripotent stem cells.