Probiotic multistrain formulations: not just a question of quantity! A pre-clinical characterization’s study of effectiveness
Marina Elli1, Chong-Yoon Lim2, Lorenzo Morelli3
Morelli31AAT-Advanced Analytical Technologies Srl,Piacenza 2Coree Srl, Milano 3Dipartimento di Scienze e Tecnologie Alimentariper una Filiera Agro-Alimentare Sostenibile(DiSTAS), Università Cattolica del Sacro Cuore,Piacenza
The probiotic market offers increasingly mixtures of strainsbelonging to different species and genera (consisting of 2-3different strains or 10 or more). The potential advantage ofcomplex products is mainly associated with the greater quantityof live cells, administered through a single intake. However, mostof the publications focus on the comparison of clinical efficacy ofmulti-strain products with respect to mono-strain products, butmade up of different probiotic strains, thus effectively comparingcompletely different formulations, dosages and methods of intake.In this paper presented a simple and useful pre-clinical probioticassessment tools can be used to compare pure probiotic strainswith different preparations in mixture, in order to guide the choiceof multi-strain formulations, exploiting the potential synergismbetween different strains, minimizing antagonisms andestablishing the most effective quantitative ratio between thecomponents of the mixture.