News in Pediatric Gastroenterology Pharmacology
Stefano Martelossi (1), Gabriele Stocco (2), Marzia Lazzerini (1)
1Clinica Pediatrica I.R.C.C.S. “Burlo Garofolo” di Trieste2Dipartimento di Scienze della Vita, Università degli Studi di Trieste
Thalidomide is a molecule with anti-TNF alfa, immunomodulatory and antiangiogenic properties. Observational studies in adults and children and a italian multicentre study in children with refractory crohn’s disease have reported encouraging result. Peripheral neuropathy is the most frequent adverse event. it’s mandatory a prevention program because its teratogenicity. Some result are found for ucerative colitis in a small pylot study.