Clinical Systematic Review
Flaminia Purchiaroni, Bruno Annibale
1Dipartimento Malattie Digestive e del Fegato, Università Sapienza, Facoltà di Medicina e Psicologia, Ospedale Sant’Andrea di Roma
Pernicious anemia (PA) is a macrocytic anemia due to vitamin B12 deficiency related to intrinsic factor deficiency. PA is associated with autoimmune-atrophic gastritis. Although PA usually occurs in elderly, it is also diagnosed in childhood. The aim of this review is to focus on diagnosis and treatment of PA under a gastroenterological and pediatric point of view.