Fascicolo monotematico "Disturbi funzionali nel bambino"
Marcella Pesce 1, Federica Pruccoli 1 , 3, Osvaldo Borrelli 1
1Department of Gastroenterology, Division of Neurogastroenterology and Motility, Great Ormond Street Hospital, London2Department of Clinical Medicine and Surgery, University of Naples Federico II; 3 Department of Medical and Surgical Sciences for Mothers, Children and Adults, University of Modena and ReggDepartment of Clinical Medicine and Surgery, University of Naples Federico II3Department of Medical and Surgical Sciences for Mothers, Children and Adults, University of Modena and Reggio Emilia
Although the conceptual premises for a braingut interaction have been known from decades, the mechanisms underlying this bidirectional cross-talk have not been systematically clarified yet. Abundant evidence has been provided for a brain-to-gut influence; whilst only recently, a new ascending pathway (gut-to-brain) is emerging, with some intriguing reports highlighting a role for the gut and the microbiota in brain development and function in health and disease.