News in Pediatric Gastroenterology Pharmacology
Silvia Riva, Francesco Cirillo, Marco Sciveres
1Epatologia Pediatrica e Trapianto di Fegato, ISMETT - University of Pittsburgh Medical Center di Palermo
Epstein Barr virus (EBV) is frequently related to post transplant lymphoproliferative disorder (diagnosis and treatment of polyclonal variants could PTLD). Early probably avoid progression toward malignant disease. Treatment strategies for PTLD include reduction of immunosuppression, targeting of Bcells with monoclonal antibodies, or chemotherapy. Adoptive immunotherapy with EBVspecific CTLs to restore a cellular immune response to EBV is an innovative and safe treatment option.